Define Ventures

We’re still buzzing from the energy at our AI + Healthcare Summit. We convened C-suite leaders from across the healthcare ecosystem to explore how AI can address real challenges and create meaningful change. And hearing from OpenAI Co-founder Greg Brockman and Chairman Bret Taylor was a rare and powerful opportunity — bringing Silicon Valley’s sharpest minds to healthcare’s most urgent questions. Topics included: 💡 How to effectively tackle barriers to adoption  📣 Using AI to amplify advocacy, equity, and personalization 🔍 Prioritizing the highest-impact use cases ⚙️ Building infrastructure that supports responsible innovation It wasn’t just about inspiration, it was about real alignment on what needs to happen next. Thank you to all of our attendees, as well as our co-sponsors Warner Thomas Sutter Health John Doerr and speakers: Instagram co-head of product Ashley Alexander GE HealthCare chief AI officer Parminder Bhatia Workday chief learning officer Chris Ernst, Ph.D. Epic president Sumit Rana Luminai co-founder & CEO Kesava Kirupa Dinakaran Layer Health co-founder & CEO David Sontag Nuna Inc. founder & CEO Jini Kim Let’s keep building.

Check out the latest from our team right here! Pharma has always been ahead of the curve and when it comes to AI, that mentality is no different. See where they're focused on delivering value, driving innovation, and what really matters to them

Pharma has officially moved past the hype cycle. We just released new research based on insights from over 40 of our close partners at Big Pharma, Big Tech, emerging pharma companies, and scaled health tech companies. The message was clear. The next 12 to 24 months will define pharma’s AI future: ⭕ 85% of pharma companies are increasing AI investment, even as broader budgets contract. ⭕ 70% of leaders are focused on cutting the cost of therapeutic discovery, but near-term ROI is coming from workflow and R&D optimization—not just the promise of new blockbuster drugs. ⭕ Big Tech and consulting firms are becoming deeply embedded, pushing beyond traditional vendor roles to reshape how pharma builds, buys, and scales AI. ⭕ AI governance is maturing fast: 80% of pharma companies now have formal AI committees, outpacing payers and providers. For pharma leaders, this is a decisive moment. Decisions made now—about partnerships, governance, and funding—will shape AI maturity for years to come. For founders building in AI and healthcare, understanding these shifts is critical to building products that actually break through. Read the full report here https://lnkd.in/gK7FbsSx Thank you to our partners at Genentech, Amgen, NVIDIA, Amazon Web Services (AWS), Oracle Life Sciences, Tempus AI, Datavant, Recursion, and others for your participation in this report.

What happens when early-stage founders get direct access to the people who know healthcare best? You get the kind of feedback that speaks volumes ⭐ ⭐⭐⭐⭐ We’re now accepting applications on a rolling basis for the next AI Fellows class. If you're building something ambitious in healthcare, let’s talk. https://lnkd.in/gnx5s_cE

🚨If you're an early-stage founder building at the intersection of healthcare and AI, this is your chance to gain an unfair advantage 🚨 The Define AI Fellows Program is an 8-week, part-time experience designed to help you accelerate your most critical decisions — from refining go-to-market strategy to closing your first enterprise customers. ✔️ Real-world frameworks and expert-led sessions ✔️ 1:1 support from Define’s investor and operator team ✔️ Access to top healthcare buyers and AI leaders ✔️ A curated community of peers navigating the same challenges Previous fellows gave the program high marks and left with sharper strategies, deeper networks, and faster traction. 📅 We’re accepting applications on a rolling basis — all applicants will be notified by the end of the month. 👉 Learn more and apply now: https://lnkd.in/gnx5s_cE Let’s build the future of healthcare, together.

AI founders: navigating healthcare is hard, but you don't have to do it alone. That's why we created our AI Fellows Program, which gives you the early-stage frameworks, insights, connections, and mentorship you need to move fast and effectively scale your company. Learn more about the program and sign up to be notified when the application window opens here: https://lnkd.in/gnx5s_cE

Our partner company Cohere Health weighs in on the news that AHIP, HHS, and CMS have outlined industry-wide commitments to improve the prior authorization process. Cohere is already delivering on or exceeding these objectives for health plans and their members nationwide including: 85% of prior authorization approvals in real time 9 million authorizations leveraging FHIR APIs in the last year 61% reduction in provider input time 50% faster medical necessity reviews with over 99% precision using artificial intelligence (AI)-enabled applications 100% use of relevant sub-specialist, board-certified physicians in the loop for clinical AI algorithms and final determinations 93% provider satisfaction across more than 600,000 providers supported

The best AI companies don’t just build tech. They reshape core processes in healthcare. That’s exactly what Layer Health. Their new partnership with Intermountain Health brings AI-enabled abstraction to 33 hospitals, helping clinical teams more efficiently and accurately report data for high-stakes registries. We’re proud to partner with the Layer team as they scale a solution that aligns automation with clinical trust, setting a new standard for operational excellence. https://lnkd.in/gZ_7bYzx

Over the next five years, what will be the biggest indicator that the U.S. healthcare system is truly moving toward a more sustainable future — government, tech advancements, or clinical and scientific advancements? Thanks to AHIP for the opportunity to have a discussion with Highmark David Holmberg, Rush University Medical Center Dr. Omar Lateef, Alignment Health Dawn Maroney, and Inovalon Mike Jones for an in-depth discussion where we covered payer and provider collaboration, patient focused care, interoperability, and AI.

If we could redesign the U.S. healthcare system from scratch, where would you start? 🟦 Government reform? 🟩 Clinical and scientific breakthroughs? 🟨 Tech and AI infrastructure? Join our founder & managing partner Lynne Chou O'Keefe at #AHIP2025 this week as she debates this very question and offer real-world strategies for long-term change, along with Highmark Health's David Holmberg, Rush University Medical Center's Dr. Omar Lateef, Alignment Health's Dawn Maroney, and Inovalon's Mike Jones.